Database of protein domains, families and functional sites
PROSITE is a database of biologically significant protein domains and patterns formulated in such a way that with appropriate computational tools it can be used rapidly and reliably to identify which domains are present in a protein (if any), hence give a hint of what the protein function might be.
Mainly useful to understand what a new protein function might be. The psscan tool will help performing the search for PROSITE patterns in a new sequence.
Because the domains and their corresponding patterns, profiles or signatures are checked manually, and carefully reviewed the precision of the domain assignment is unrivalled.
Sigrist CJA, de Castro E, Cerutti L, Cuche BA, Hulo N, Bridge A, Bougueleret L, Xenarios I. New and
continuing developments at PROSITE. Nucleic Acids Res. 2012; doi: 10.1093/nar/gks1067 (PDF)
Sigrist CJA, Cerutti L, Hulo N, Gattiker A, Falquet L, Pagni M, Bairoch A, Bucher P. PROSITE: a documented database using patterns and profiles as motif descriptors. Brief Bioinform. 3:265-274(2002) (PDF)
is developed and copyrighted by SIB Swiss Institute of Bioinformatics and its
exclusive commercial representative GeneBio.
Access is free for non-commercial use. Access by commercial entities is subject to the licensing conditions outlined in the GeneBio License Agreement (PDF).
Please contact us for further details.