GeneBio

Our software tools and resources

Innovative software for 2-D gel and blot analysis The software is suitable for a wide range of applications and methods, including conventional 2-DE and 2-DIGE (difference gel electrophoresis) experiments, Western blots, and other multiplexed technologies.
The advanced normalization options can be applied, for example, to host cells expressing recombinant protein, or to analysis of samples from different subcellular fractions. This capability opens up new applications, from expression analysis to process development for monoclonal antibodies.
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Database of protein domains, families and functional sites PROSITE is a database of biologically significant protein domains and patterns formulated in such a way that with appropriate computational tools it can be used rapidly and reliably to identify which domains are present in a protein (if any), hence give a hint of what the protein function might be. More...
Two-dimensional polyacrylamide gel electrophoresis database The SWISS-2DPAGE database assembles data on proteins identified on various 2-D PAGE and SDS-PAGE maps. Each SWISS-2DPAGE entry contains textual data on one protein, including mapping procedures, physiological and pathological information, experimental data (isoelectric point, molecular weight, amino acid composition, peptide masses) and bibliographical references. In addition to this textual data, SWISS-2DPAGE provides several 2-D PAGE and SDS-PAGE images showing the experimentally determined location of the protein, as well as a theoretical region computed from the sequence protein, indicating where the protein might be found in the gel. More...
MegaClust is a service allowing companies to analyze their flow cytometry datasets MegaClust is a service allowing companies to analyze their flow cytometry datasets. It results in the exhaustive and unbiased identification and characterization of cell groups across samples, i.e. cells sharing similar phenotypes, which is key for downstream analyses (e.g. stratification of individuals). MegaClust sample merging enables complex analyses that require sample comparisons. More...
LC-MSMS software for small molecule identification with confidence SmileMS software is designed to identify analyses from mass spectrometry (MS) spectra of fragmented molecules via a spectral library search approach. It can be used both for targeted and untargeted screening methods. More...
Database for studying, modelling or visualizing non-natural amino acids SwissSidechain is a structural and molecular mechanics database of hundreds of non-natural amino-acid sidechains that can be used to study, model or visualize non-natural amino acids and to study in silico their insertion into natural peptides or proteins. More...
Compound optimization in drug design SwissBioIsotere is a knowledgebase that provides information on more than 4.5 million molecular substructural replacements extracted from literature and that are useful for compound optimization in drug design. It provides a tool for replacements for a single substructure (e.g. an amide group) or a particular substructure of interest (e.g. carboxylic acid vs tetrazole). More...
A webserver for target prediction of bioactive small molecules SwissTargetPrediction is a webserver for target prediction of bioactive small molecules in human and other vertebrates in order to understand the molecular mechanisms underlying a given phenotype or bioactivity, to rationalize possible side-effects or to predict off-targets of known molecules. Using a combination of 2D and 3D similarity measures, it compares the query molecule to a library of 280'000 compounds active on more than 2000 targets of 5 different organisms. More...
Topology and parameters for small organic molecules compatible with the CHARMM all atoms force field, for use with CHARMM and GROMACS SwissParam is a webserver that provides topology and parameters for small organic molecules. These parameters are intended for drug design type calculations, such as docking, minimizations, rapid binding energy estimation (LIECE), etc. More...